The ‘Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke Trial-2’ (RIGHT-2)

• Professor Philip MW Bath, University of Nottingham
• Professor Timothy England, University of Nottingham
• Professor John Potter, University of East Anglia
• Professor Christine Roffe, North Staffordshire Combined Healthcare Trust
• Professor Alan Montgomery, University of Nottingham
• Professor Thompson G Robinson, University of Leicester
• Dr Chris I Price, University of Newcastle upon Tyne
• Professor Joanne M Wardlaw, University of Edinburgh
• Professor A Niroshan Siriwardena, University of Lincoln

• To compare the difference between GTN and no GTN in death, disability, dependency, mood, cognition, and quality of life.

Secondary objectives

• To assess the safety and tolerability of GTN in suspected ultra-acute stroke.
• To compare the difference in peripheral blood pressure, central blood pressure, heart rate, and its derivatives between patients randomised to GTN or no GTN.

Dixon M, Appleton JP, Scutt P, Woodhouse LJ, Haywood LJ, Havard D, Williams J, Siriwardena AN, Bath PM on behalf of the RIGHT-2 Investigators (2022). Time intervals and distances travelled for pre-hospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2). BMJ Open 12: e060211.

Tunnage B, Woodhouse LJ, Dixon M, Anderson C, Ankolekar S, Appleton J, Cala L, England T, Krishnan K, Havard D, Mair G, Muir K, Phillips S, Potter J, Price C, Randall M, Robinson TG, Roffe C, Sandset E, Siriwardena AN, Scutt P, Wardlaw JM, Sprigg N, Bath PM on behalf of the RIGHT-2 Investigators (2022). Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. BMC Emergency Medicine 22: 2.

Woodhouse LJ, Appleton JP, Ankolekar S, England TJ, Mair G, Muir K, Price CI, Pocock S, Randall M, Robinson TG, Roffe C, Sandset EC, Saver JL, Siriwardena AN, Sprigg N, Wardlaw JM, Bath PM (2023). Pre-hospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): effects on outcomes at day 365 in a randomised, sham-controlled, blinded, phase III, superiority ambulance-based trial. BMJ Neurology Open 5: e000424.

Appleton JP, Woodhouse LJ, Anderson CS, Ankolekar S, Cala L, Dixon M, England TJ, Krishnan K, Mair G, Muir KW, Potter J, Price CI, Randall M, Robinson TG, Roffe C, Sandset EC, Saver JL, Shone A, Siriwardena AN, Wardlaw JM, Sprigg N, Bath PM on behalf of the RIGHT-2 Investigators (2024). Pre-hospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial. Stroke and Vascular Neurology; svn-2022-001634.

Dixon M, Appleton JP, Scutt P, Woodhouse LJ, Haywood LJ, Havard D, Williams J, Siriwardena AN, Bath PM on behalf of the RIGHT-2 Investigators (2022). Time intervals and distances travelled for pre-hospital ambulance stroke care: data from the randomised-controlled ambulance-based Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2). BMJ Open 12:e060211.

Website: http://right-2.ac.uk/

Social: potential for prevention of long-term disability and suffering from stroke.